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Cook, Paul
One or more keywords matched the following items that are connected to Cook, Paul
Item TypeName
Concept Cysteine Synthase
Academic Article Time-resolved fluorescence of O-acetylserine sulfhydrylase.
Academic Article Pyridoxal 5'-phosphate-dependent alpha,beta-elimination reactions: mechanism of O-acetylserine sulfhydrylase.
Academic Article A three-dimensional homology model of the O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Structure, mechanism, and conformational dynamics of O-acetylserine sulfhydrylase from Salmonella typhimurium: comparison of A and B isozymes.
Academic Article Effect of mutation of lysine-120, located at the entry to the active site of O-acetylserine sulfhydrylase-A from Salmonella typhimurium.
Academic Article Role of Histidine-152 in cofactor orientation in the PLP-dependent O-acetylserine sulfhydrylase reaction.
Academic Article Design of O-acetylserine sulfhydrylase inhibitors by mimicking nature.
Academic Article The multifaceted pyridoxal 5'-phosphate-dependent O-acetylserine sulfhydrylase.
Academic Article pH dependence of the absorbance and 31P NMR spectra of O-acetylserine sulfhydrylase in the absence and presence of O-acetyl-L-serine.
Academic Article Kinetic isotope effects as a probe of the beta-elimination reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Formation of the alpha-aminoacrylate immediate limits the overall reaction catalyzed by O-acetylserine sulfhydrylase.
Academic Article Tryptophan luminescence as a probe of enzyme conformation along the O-acetylserine sulfhydrylase reaction pathway.
Academic Article Time-resolved fluorescence of O-acetylserine sulfhydrylase catalytic intermediates.
Academic Article Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Characterization of the allosteric anion-binding site of O-acetylserine sulfhydrylase.
Academic Article Alpha,beta-elimination reaction of O-acetylserine sulfhydrylase. Is the pyridine ring required?
Academic Article Surface-exposed tryptophan residues are essential for O-acetylserine sulfhydrylase structure, function, and stability.
Academic Article Mechanism of the addition half of the O-acetylserine sulfhydrylase-A reaction.
Academic Article (31)P NMR studies of O-acetylserine sulfhydrylase-B from Salmonella typhimurium.
Academic Article Identification of the structural determinants for the stability of substrate and aminoacrylate external Schiff bases in O-acetylserine sulfhydrylase-A.
Academic Article Isozyme-specific ligands for O-acetylserine sulfhydrylase, a novel antibiotic target.
Academic Article Mechanism of O-acetylserine sulfhydrylase fromSalmonella typhimurium LT-2.
Academic Article Substitution of pyridoxal 5'-phosphate in the O-acetylserine sulfhydrylase from Salmonella typhimurium by cofactor analogs provides a test of the mechanism proposed for formation of the alpha-aminoacrylate intermediate.
Academic Article A change in the internal aldimine lysine (K42) in O-acetylserine sulfhydrylase to alanine indicates its importance in transimination and as a general base catalyst.
Academic Article Cysteine 42 is important for maintaining an integral active site for O-acetylserine sulfhydrylase resulting in the stabilization of the alpha-aminoacrylate intermediate.
Academic Article O-acetylserine sulfhydrylase.
Academic Article Structure and mechanism of O-acetylserine sulfhydrylase.
Academic Article A rapid purification procedure and computer-assisted sulfide ion selective electrode assay for O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article A two-step process controls the formation of the bienzyme cysteine synthase complex.
Academic Article Fine tuning of the active site modulates specificity in the interaction of O-acetylserine sulfhydrylase isozymes with serine acetyltransferase.
Academic Article Product binding to the alpha-carboxyl subsite results in a conformational change at the active site of O-acetylserine sulfhydrylase-A: evidence from fluorescence spectroscopy.
Academic Article Three-dimensional structure of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Catalytic competence of O-acetylserine sulfhydrylase in the crystal probed by polarized absorption microspectrophotometry.
Academic Article Identification of an allosteric anion-binding site on O-acetylserine sulfhydrylase: structure of the enzyme with chloride bound.
Academic Article Detection of intermediates in reactions catalyzed by PLP-dependent enzymes: O-acetylserine sulfhydrylase and serine-glyoxalate aminotransferase.
Academic Article Characterization of the S272A,D site-directed mutations of O-acetylserine sulfhydrylase: involvement of the pyridine ring in the alpha,beta-elimination reaction.
Academic Article Interaction of serine acetyltransferase with O-acetylserine sulfhydrylase active site: evidence from fluorescence spectroscopy.
Academic Article Exploring O-acetylserine sulfhydrylase-B isoenzyme from Salmonella typhimurium by fluorescence spectroscopy.
Academic Article salmonella typhimurium/enzymol.
Academic Article Cysteine synthetase from Salmonella typhimurium LT-2. Aggregation, kinetic behavior, and effect of modifiers.
Academic Article A reaction mechanism from steady state kinetic studies for O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2.
Academic Article Overall mechanism and rate equation for O-acetylserine sulfhydrylase.
Academic Article Resolution of pyridoxal 5'-phosphate from O-acetylserine sulfhydrylase from Salmonella typhimurium and reconstitution of apoenzyme with cofactor and cofactor analogues as a probe of the cofactor binding site.
Academic Article Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction.
Academic Article Acid-base chemical mechanism of O-acetylserine sulfhydrylases-A and -B from pH studies.
Academic Article Crystallization and preliminary X-ray data for the A-isozyme of O-acetylserine sulfhydrylase from Salmonella typhimurium.
Academic Article Kinetic mechanisms of the A and B isozymes of O-acetylserine sulfhydrylase from Salmonella typhimurium LT-2 using the natural and alternative reactants.
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  • Cysteine Synthase